The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis?
نویسندگان
چکیده
منابع مشابه
The role of level and function of High Density Lipoprotein (HDL) in Cardiovascular Diseases
High-density lipoprotein (HDL) is a set of particles with heterogeneous structures that have different functions due to various compounds including surface charge, size, lipid, and protein compounds. Several prospective epidemiological studies have demonstrated that there is a clear inverse relationship between serum HDL concentration and risk of coronary heart disease, despite this relationshi...
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A low level of high-density lipoprotein cholesterol (HDL-C) is an important cardiovascular risk factor, and is commonly seen in patients with type 2 diabetes mellitus. An inverse relationship between HDL-C concentration and cardiovascular risk has been consistently shown in clinical and epidemiological studies. In the well-known Framingham Heart Study, HDL-C was found to be the best predictor o...
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C linical intervention studies have provided clear evidence that low-density lipoproteins are causally involved in the development of atherosclerosis. In contrast, data for highdensity lipoproteins (HDLs) are still inconclusive. A number of antiatherogenic properties have been ascribed to HDL, but the hypothesis that HDL is causally related to cardiovascular disease has been challenged seriousl...
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Determining arterial macrophage expression is an important goal in the molecular imaging of atherosclerosis. Here, we compare the efficacy of two synthetic, high density lipoprotein (HDL) based contrast agents for magnetic resonance imaging (MRI) of macrophage burden. Each form of HDL was labeled with gadolinium and rhodamine to allow MRI and fluorescence microscopy. Either the 37 or 18 amino a...
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High-density lipoproteins (HDL) are typically defined as lipoprotein particles with buoyant densities from 1.063 to 1.21 g/mL and having apolipoprotein AI (apoAI) as the major apolipoprotein species. It has become increasingly appreciated that the HDL population consists of a collection of particles with diverse sizes, structures, and composition and functional properties that are thought to in...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2010
ISSN: 0022-2275
DOI: 10.1194/jlr.r001610